ROBERT D. PHAIR, Ph.D.

BioInformatics Services
Integrative BioInformatics, Inc.

Phone: 1.650.518.6501
Web: www.bioinformaticsservices.com
www.integrativebioinformatics.com
E-mail: rphair "at" integrativebioinformatics.com

PROFESSIONAL EXPERIENCE:

2003 Scientific Advisory Board, Chemical Industry Institute of Toxicology, Research Triangle Park, NC
2001 - date Founder, Chief Scientific Officer, Integrative BioInformatics, Inc., Mountain View, CA
1996 - date Principal and Senior Consultant, BioInformatics Services, Rockville, MD
1999 - 2001 Scientific Advisory Board, Zone Therapeutics Inc., College Park, MD
1998 - date Faculty Member, FAES Graduate School at NIH, Bethesda, MD
1987 - 96 Associate Professor of Biomedical Engineering, The Johns Hopkins University School of Medicine
1987 - 96 Associate Professor of Physiology, The Johns Hopkins University School of Medicine
1986 - 87 Assistant Professor of Biomedical Engineering, The Johns Hopkins University School of Medicine
1979 - 87 Assistant Professor of Physiology, The Johns Hopkins University School of Medicine
1978 - 79 NIH NRSA Fellow in Endocrinology and Metabolism
1971 - 73 Staff Associate, Mathematician with Dr. Mones Berman, Mathematical Research Branch, National Institute of Arthritis and Metabolic Diseases, NIH, and Laboratory of Theoretical Biology, National Cancer Institute, NIH
1969 - 71 Systems Analyst/Computer Programmer, National Air Pollution Control Administration, Commissioned Officer, U.S. Public Health Service.
1968 - 69 Graduate Program in Biomedical Engineering, Northwestern University, Evanston, Illinois. Admitted to Candidacy. Thesis work on Observability and Controllability of Biological Control Systems with Dr.R.W.Jones. Program interrupted by active duty as Commissioned Officer in the U.S. Public Health Service.

EDUCATION:

1978 - 79 Post-doctoral training Cellular Endocrinology with Drs. Sumer B. Pek and William E. Lands, Departments of Medicine and Biochemistry, University of Michigan
1977 - 78 Post-doctoral training Cardiovascular Physiology with Dr. Harvey V. Sparks, Department of Physiology, University of Michigan
1973 - 77 Ph.D. in Physiology, University of Michigan, Ann Arbor
1971 - 73 Staff Fellow in Computational Biology and Modeling with Dr. Mones Berman, NIH, Bethesda, MD
1968 - 69 M.S. program in Biomedical Engineering, Northwestern University, Evanston, IL
1964 - 68 S.B. in Electrical Engineering and Computer Science, Massachusetts Institute of Technology

AWARDS:

2001 Berman-Zech Award for outstanding achievement in kinetics, KinMet2001, Arlington, VA

INVITED PRESENTATIONS AT NATIONAL AND INTERNATIONAL MEETINGS:

2004 Workshop on Kinetic Analysis of FRAP and FLIP experiments, International Congress on Systems Biology, Heidelberg, Germany
2003 ASCB Special Interest Subgroup - Software for Computational Cell Biology, San Francisco, CA
2003 International Symposium on Computational Cell Biology, Lenox, MA
2002 Guest Lecturer, NCRR Scientific Resources PI Meeting, Bethesda, MD
2002 Dynamics Days, Life Sciences, Heidelberg, Germany
2002 Gordon Research Conference on Reversible Associations in Structural and Molecular Biology, Ventura, CA
2000 American Chemical Society National Meeting, San Francisco, CA
2000 Computational Modeling of Biological Systems: From Gene to Organ, Hilton Head Island, SC
2000 Association of Biomolecular Resource Facilities (ABRF2000) , Bellevue, WA
1999 Gordon Research Conference on Analytical Chemistry, Henniker, NH
1998 Satellite Meeting on Lipid and Lipoprotein Kinetics, American Heart Association, Dallas, TX (Chair and speaker)
1998 Gordon Conference on Lipoprotein Metabolism, Meriden, NH (poster)
1997 Satellite Meeting on Biomedical Kinetics, American Heart Association, Orlando, FL (Chair and speaker)
1997 Gordon Conference on Lipid Metabolism, Meriden, NH (poster)
1996 Satellite Meeting on Biomedical Kinetics and Modeling, American Heart Association, New Orleans, LA (Chair and speaker)
1996 Graduate Research Education And Training Conference, Association of American Medical Colleges, Phoenix, AZ
1996 Gordon Conference on Lipid Metabolism, Meriden, NH (poster)
1996 Symposium on In Vivo Tracer Kinetics and Modeling, NIH, Bethesda
1995 Satellite Meeting on Lipoprotein Kinetics and Modeling, American Heart Association, Anaheim, CA (Invited Chair and speaker)
1994 FASEB Summer Research Conference on Calcium and Cell Function, Saxtons River, VT (poster)
1993 National Meeting of the Specialized Centers of Research in Arteriosclerosis, Seattle, WA
1993 First ever Gordon Conference on Calcium Signalling, Henniker, NH (poster)
1992 Second International Symposium on Reverse Cholesterol Transport and Coronary Heart Disease, Fort Worth, TX
1992 FASEB Summer Research Conference on Calcium and Cell Function, Saxtons River, VT (poster)
1991 Fourth FASEB Summer Research Conference on Smooth Muscle, Copper Mountain, CO (poster)
1989 International Symposium on Reverse Cholesterol Transport and Coronary Heart Disease, Fort Worth, TX
1988 Calcium Antagonists and Atherosclerosis Workshop, Philadelphia, PA
1988 Second International Workshop on High Density Lipoproteins and Atherosclerosis, Leeds, England
1988 Third FASEB Summer Research Conference on Smooth Muscle, Saxtons River, VT (poster)
1987 - 89 Annual Workshops on Kinetic Modeling in Biology and Medicine, Resource Facility for Kinetic Analysis, Seattle, WA
1987 Plenary Session Speaker, VIIth International Washington Spring Symposium, Cell Calcium Metabolism '87, Washington, DC
1986 Gordon Conference on Lipid Metabolism, Meriden, NH (poster)
1985 Keynote presentation, Satellite Conference on Lipoprotein Kinetics, Seventh International Atherosclerosis Symposium, Melbourne, Australia
1985 Second FASEB Summer Research Conference on Smooth Muscle, Saxtons River, VT
1984 Conference on Mathematical Modeling in Biomedical Research, Fogarty International Center, NIH, Bethesda, MD
1982 FASEB Summer Research Conference on Smooth Muscle, Saxtons River, VT (poster)
1980 NIH Workshop on Plasma Lipoprotein Kinetics, Phoenix, AZ
1979 NIH Workshop on Simulation and Simulation Resources, Seattle, WA
1973 Deuel Conference on Lipids, Carmel, CA

OTHER INVITED PRESENTATIONS

2006 Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX
2004 Dept. Cell Biology, ETH Zurich
2003 Protein Trafficking Interest Group NIH
2002 National Center for Genome Resources, Santa Fe, NM
2001 RNA Interest Group, National Institutes of Health, Bethesda, MD
2000 Protein Trafficking Interest Group, National Institutes of Health, Bethesda, MD
2000 RNA Interest Group, National Institutes of Health, Bethesda, MD
1999 Protein Trafficking Interest Group, National Institutes of Health, Bethesda, MD
1999 Laboratory of Cell Biology, National Heart Lung and Blood Institute, NIH, Bethesda, MD
1998 Protein Trafficking Interest Group, National Institutes of Health, Bethesda, MD
1997 Protein Trafficking Interest Group, National Institutes of Health, Bethesda, MD
1997 Otsuka America Pharmaceuticals, Rockville, MD
1991 Mid-Atlantic Lipid Society, Baltimore, MD
1990 University of Washington, Department of Medicine, Division of Endocrinology, Seattle, WA
1989 Mid-Atlantic Lipid Society, Bethesda, MD
1988 Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC
1986 Medical College of Pennsylvania, Department of Biochemistry and Physiology, Philadelphia, PA
1984 National Institutes of Health, National Cancer Institute, Laboratory of Theoretical Biology, Bethesda, MD
1983 University of Virginia, Department of Physiology, Charlottesville, VA
1982 Washington University, Department of Medicine, St Louis, MO
1981 University of Florida, Departments of Medicine and Biochemistry

MEMBERSHIPS IN PROFESSIONAL SOCIETIES:

2001 - date Society for Mathematical Biology
1999 - date American Society for Cell Biology
1989 - date Fellow, Council on Arteriosclerosis, American Heart Association
1977 - 2002 American Physiological Society
1974 - date American Association for the Advancement of Science
1977 - date Federation of American Societies for Experimental Biology
1986 - date Mid-Atlantic Lipid Society, Charter member
1977 - date American Heart Association
1988 - date National Institutes of Health Alumni Association
1982 - 86 Society for Mathematical Biology
1968 - 73 Institute of Electrical and Electronics Engineers

RESEARCH SUPPORT:

NIH R43 GM066611 (4/03 to 12/06) Database Software for Complex Cell Biological Pathways (SBIR Phase I and Phase II support for Integrative BioInformatics, Inc.), PI

NIH P50 HL47212 (12/91 to 11/96) Specialized Center of Research (SCOR) in Arteriosclerosis Dr. P.O. Kwiterovich, P.I. Co-investigator, responsible for computational biology (Projects II and III)

NIH RR02176 (6/90 to 12/93) A Resource Facility for Kinetic Analysis (RFKA) Subcontract from Dr. D.M. Foster (PI) Participated in Specification of Functionality and Design of User Interface for new kinetic analysis software package

NIH Institutional Research Grant (12/88 to 11/89) Cellular Calcium and Atherosclerosis

NIH R01 HL35487 (12/85 to 11/88) Kinetics of Plasma Lipoprotein Assembly and Secretion, PI Computational biology of plasma lipoprotein assembly and secretion.

NIH R01 HL34976 (9/85 to 8/88) Progestin and Estrogen Effects on Lipoprotein Metabolism Collaboration with Drs. D. Applebaum-Bowden (PI) and W.R. Hazzard Computational biology, experimental design, and data analysis.

NIH R01 HL33225 (12/84 to 11/89) Sex Steroid Modulation of Plasma Lipoprotein Metabolism Collaboration with Drs. William R. Hazzard (PI) and D. Applebaum-Bowden Computational biology, experimental design, and data analysis.

MEMBERSHIP ON NATIONAL PEER REVIEW COMMITTEES:

2006 NIH Cell Structure and Function, Cell Biology Integrated Review Group, ad hoc reviewer
2003 NIH Cell Development and Function 5, ad hoc reviewer
2003 NIH Special Emphasis Review Panel
2001 NIH Special Emphasis Review Panel
2000 NIH Cell Biology Study Section (CBY2), ad hoc reviewer
1999 NIH Special Emphasis Review Panel
1999 NIH Cell Biology Study Section (CBY2), ad hoc reviewer
1989 NIH Biomedical Sciences (Biotechnology) Study Section
1987 NIH Metabolic Pathology Study Section, ad hoc reviewer
1986 - 90 Reviewer for The Whitaker Foundation
1985 NIH Metabolism Study Section, ad hoc reviewer
1985 NIH Biochemistry Study Section, ad hoc reviewer
1985 NIH Special Study Section on Mathematical Modelling and Biostatistics
1984 NIH/NIGMS Special Study Section
1984 - 89 Reviewer for NSF Metabolic Biology Program
1981 NIH Biochemistry Study Section, Site Visit Team
1981 - 89 Reviewer for NSF Regulatory Biology Program
1980 NIH/NIGMS Special Study Section

OTHER PEER REVIEW ACTIVITIES:

Critical reviewer of 3 - 7 manuscripts per year for:

Nature Cell Biology
Biotechnology Progress
Metabolism
Journal of Lipid Research
Arteriosclerosis, Thrombosis and Vascular Biology
Circulation Research
American Journal of Physiology, Cell Physiology
American Journal of Physiology, Heart and Circulatory Physiology
American Journal of Physiology, Regulatory & Integrative Physiology
Science
Hypertension
Journal of Clinical Investigation
Journal of Theoretical Biology
Annals of Biomedical Engineering
Journal of Nutrition
Analytical Biochemistry

NATIONAL RESEARCH ADMINISTRATIVE ACTIVITIES:

2003 Scientific Advisory Board, CIIT, Research Triangle Park, NC
2002 NCRR Working Group on Computational Cell Biology, Farmington, CT
2002 ASCB Abstract Programming Committee
1996 - date Founder and maintainer, BIS Computational Biology Forum, a discussion group on the World Wide Web.
1996 - 2001Organizer, Kinetics Satellite Meetings. Specialty group meetings held in tandem with national scientific meetings such as the Scientific Sessions of the American Heart Association, and the American Association for Clinical Research.
1988 - 99 Specification Committee for design of new simulation and modeling software, SAAM II, NIH, NCRR Resource Facility for Kinetic Analysis, University of Washington, Seattle
1987 - 88 National Research Network Review Committee, Computer Science and Technology Board, National Research Council, National Academy of Sciences
1986 - 98 National Advisory Council, National Resource Facility for Kinetic Analysis, University of Washington, Seattle
1987 - 89 Secretary-Treasurer, Mid-Atlantic Lipid Society
1983 - 84 Simulation Analysis And Modeling Committee, Laboratory of Mathematical Biology, National Cancer Institute, NIH
1979 Working Group on Simulation and Simulation Resources, NIH Division of Research Resources

PROFESSIONAL ADMINISTRATIVE ACTIVITIES:

At The Johns Hopkins University

1992 - 95 Health Professions Recommendation Committee
1990 - 94 Associate Professor Promotions Committee
1989 - 90 Assistant Professor Appointment and Review Committee
1987 Organizing Committee, In House Cell Biology Symposium
1984 - 86 Advisory Board of the Medical Faculty, Medical School Council representative
1984 - 86 Vice Chairman, Medical School Council
1985 - 86 Chairman, Medical School Council Subcommittee on Computing and Information Management
1985 - 89 Executive Committee, Integrated Academic Information Management Systems Planning, Welch Medical Library
1986 - 89 Medical Informatics Subcommittee, IAIMS, Welch Medical Library
1984 - 85 Medical School Council Subcommittee on Appointments and Promotions
1983 - 96 School of Medicine Computing and Networking Committee
1983 - 93 Medical Scientist Training Program (MD/PhD) Steering Committee
1983 - 85 Chairman, Medical School Council Subcommittee on Computing Facilities
1982 - 86 Medical School Council, Department of Physiology representative

TEACHING AWARDS:

1996 Old Gold and Sable Award, for distinguished service to the Johns Hopkins University Undergraduate Campus Community
1996 Selected as Marshal for Engineering, Johns Hopkins University Commencement
1993 Nominated for the American Physiological Society's Arthur C. Guyton Physiology Teacher of the Year Award
1992 Outstanding Faculty Award presented by the Johns Hopkins University Undergraduate Student Council
1990 W. Barry Wood, Jr. Award for Excellence in Teaching (voted by first and second year medical and graduate students at the Johns Hopkins School of Medicine)
1989 Dean's commendation for special teaching excellence in Cardiovascular Physiology

TEACHING ACTIVITIES:

1998 - 2002 Integrative Bioinformatics, a course (BIOC 509) in the FAES Graduate School at the NIH, Bethesda, MD
1997 Organizer, Lecturer, Tutor, Workshop on Formulation and Testing of SAAM II Kinetic Models, Ohio State University, Columbus, OH
1996 Lecturer, Tutor, SAAM II Kinetic Modelling Workshop, City University, London, UK
1996 Lecturer, Tutor, SAAM II Kinetic Modeling Workshop, Institute for Food Research, Norwich, UK
1996 Workshop on Becoming an Outstanding Science Teacher, The Johns Hopkins University, Baltimore, MD
1990 - 96 Second Messenger Control Systems (graduate and advanced undergraduate course in computer modeling of cellular systems)
1988 - 89 The Basic Principles of Tracer Kinetics, Workshop at the Annual Meeting of the Resource Facility for Kinetic Analysis, Seattle, WA
1987 How to Start a Modeling Project, Workshop at the Annual Meeting of the Resource Facility for Kinetic Analysis, Seattle, WA.
1986 - 96 Principal Undergraduate Academic Advisor to approximately 30 Biomedical Engineering majors per year.
1986 - 94 Manager, Cardiovascular Physiology, First Year Medical and Graduate Physiology Course (approximately 130 students per year)
1986 - 96 Lecturer, Cell Biology and Cellular Physiology, Physiological Foundations for Biomedical Engineering, Johns Hopkins University
1982 - 96 Principal lecturer, Cardiovascular Physiology, First Year Medical and Graduate Physiology Course (7 lectures per year)
1982 - 85 Manager, First Year Medical and Graduate Physiology Course (approximately 130 students per year)
1980 - 91 Mathematical Models of Biological Systems (advanced undergraduate/graduate course, approximately 25 students per year)
1980 - 88 Educational Council of The Massachusetts Institute of Technology
1979 - 96 Consultant and mentor for faculty members and post-docs from Physiology, Biochemistry, Pediatrics, Cell Biology, and Environmental Health Sciences on issues pertaining to kinetics, modeling, and computational biology.

RESEARCH SUPERVISION AND TRAINING:

Graduate and Medical Students

1992 - 96 Smadar (Madi) A. Lapidot (Ph.D. in Biomedical Engineering, 1996)
Individual NSF Graduate Fellowship
AAUW Foundation Engineering Dissertation Fellowship (1995-96)
Travel fellowship to attend 1996 meeting of the International Biophysical Union, Amsterdam, Netherlands
Certificate of Merit, Johns Hopkins University School of Medicine, Young Investigator Day, 1996

1984 - 89 S. Adam Strickberger (M.D., 1987)
Harold Lamport Research Prize of the Johns Hopkins School of Medicine for his work in our lab, 1986
Resident in Internal Medicine at The Johns Hopkins Hospital
Cardiology Fellow, Brigham and Womens Hospitals, Boston, MA
Instructor, Cardiology, University of Michigan
Assistant Professor, Cardiology, University of Michigan
Associate Professor, Cardiology, University of Michigan

1983 - 87 Leslie N. Russek (Ph.D. in Biomedical Engineering, 1987)
NSF postdoctoral fellow with Dr. David Warshaw, Department of Physiology and Biophysics, University of Vermont.
Professional Physical Therapist and Clinical Researcher

1980 - 84 Chi-Ming Hai (Ph.D. in Physiology, 1984)
Postdoctoral fellow with Dr. Richard Murphy, Department of Physiology, University of Virginia.
Associate Professor of Physiology and Biophysics at Brown University.

Postdoctoral Fellows

1987 - 88 Austin E. Brooks, Ph.D. Professor of Biology, Wabash College, Crawfordsville, IN.
Sabbatical year in our lab as a Dana Foundation Fellow in Biomedical Engineering.

1984 - 86 Sandra Howell, Ph.D.
Associate Professor of Biomedical Engineering at the University of Southern California.

1981 - 82 David P. Dempsher, M.D., Ph.D.
Resident in Pediatrics at Vanderbilt University
Postdoctoral research fellow in the Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.

Undergraduate Students

1994 - 96 Mohamad Allaf, B.S.
Winner - 1994-95 Biomedical Engineering Undergraduate Research Award
M.D. Program, Johns Hopkins University

1994 - 96 Tracy Vogrin , B.S.

1993 - 96 Guy Schecter, B.S.
Awarded 1995 Provost's Award for Research and Excellence, Winner - 1995-96 Biomedical Engineering Undergraduate Research Award Ph.D. Program, Biomedical Engineering, Johns Hopkins University

1993 - 95 Eric Halsey, B.S.
M.D. Program, University of Kansas

1993 - 94 Brian Gates, B.S.
Ph.D. Program in Biochemical Engineering, University of California, Davis

1992 - 95 Nathan Hoffmann, B.S.
M.D./Ph.D. Program, University of Minnesota

1992 - 93 Rajjit Abrol, B.S.
M.D. program, Emory University

1992 - 95 Bill K. Huang, B.S.
Awarded 1993 GE Undergraduate Research Opportunities Program Summer Fellowship for work in our lab
Awarded Provost's Award for Research and Excellence
Winner - 1993-94 Biomedical Engineering Undergraduate Research Award
Awarded 1994 Outstanding Effort in Research in Biomedical Engineering Award
M.D. program, Northwestern University

1991 - 94 Amir Fayazi, B.A.
Awarded NSF Summer Fellowship for work in our lab
Winner - 1992-93 Biomedical Engineering Undergraduate Research Award
Awarded Provost's Award for Research and Excellence
M.D. program, Washington University, St. Louis

1989 - 91 Mary Katherine Horner, B.S.
Winner - 1990-91 Biomedical Engineering Undergraduate Research Award
Ph.D. program in Physiology/Membrane Biology University of Maryland

1989 - 91 Joseph D. Neff, B.S.
Ph.D. in Biomedical Engineering (1996) University of Pennsylvania

1988 - 90 Sang Kim, B.S.
M.D. program SUNY Downstate Medical Center

1987 - 88 Agustin Ifaraguerri, B.S.
Ph.D. program in Biomedical Engineering University of Michigan, Ann Arbor
Individual NSF predoctoral fellowship

1986 - 87 Sudip Tripathy, B.S.
M.D. program, University of Kansas

Thesis Committee Participation:

1996 S. Lapidot, Ph.D. in Biomedical Engineering
1996 D. Mears, Ph.D. in Biomedical Engineering
1994 L. Dobrunz, Ph.D. in Biomedical Engineering
1994 J. Imredy, Ph.D. in Biomedical Engineering
1993 M.S. deLeon, M.S. in Engineering
1991 N.E. Giacobbe, M.S. in Engineering
1991 C.H. Wang, M.S. in Engineering
1991 E.B. Hasse, Ph.D. in Biomedical Engineering
1989 W.C. Rose, Ph.D. in Biomedical Engineering
1988 S.F. Nemerson, M.S. in Engineering
1988 F.S. Wu, Ph.D. in Physiology
1987 L.N. Russek, Ph.D. in Biomedical Engineering
1986 V.O. Ulrich, Ph.D. in Physiology
1986 S.J. Hassenbusch, Ph.D. in Pharmacology
1984 C.M. Hai, Ph.D. in Physiology
1982 D.P. Dempsher, Ph.D. in Biomedical Engineering
1980 M.G. Bolton, Ph.D. in Physiology

Publications