This cybertextbook is needed by advanced undergraduate and graduate students and professionals in the biomedical sciences or in biomedical engineering who want or need to use modern computer modeling approaches to test theories against experimental data. The cybertextbook is focussed on practical application; it is a handbook, a guidebook, and a map for the process of formulating and testing biological models. The reader will learn a step-by-step method, applicable to a wide range of biological problems. The aim is to add useful and powerful tools to the reader's repertoire of scientific skills, and to make the reader self-sufficient in the use of these tools.

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